Increased exposure w/ potent CYP1A2 inhibitors eg, ciprofloxacin, fluvoxamine. Decrease oral bioavailability of midazolam. Decreased metabolism & increased plasma conc w/ potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, voriconazole), PIs, erythromycin or clarithromycin. Increased metabolism & decreased plasma conc w/ potent CYP3A4 inducers eg, rifampicin, phenytoin, carbamazepine, barbiturates or St. John's Wort (
Hypericum perforatum). Increased INR & bleeding events w/ coumarin-derived anticoagulants eg, warfarin. Potential increase for statin-induced myopathy (eg, rhabdomyolysis) w/ statins. Altered distribution &/or elimination w/ P-gp inhibitors eg, cyclosporine, verapamil. Decreased exposure & max conc w/ PPIs (eg, omeprazole), H
2-receptor antagonist (eg, ranitidine). Increased conc by capecitabine. Proteasome inhibitors (eg, bortezomib).